Insights Into Cod-Liver Oil with Ciperus Esculentus, Phoenix Dactylifera and Soybean on Oxidative Stress Markers Profile in Normal Male Wistar Rats

Research Article

Abstract

This study determine the effect of cod liver oil with soybean, Cyperus Esculentus, and phoenix dactylifera on oxidative stress markers, weight and fasting blood sugar level. Fifty six male healthy wistar rats with weight ranging from 162g to 301g housed in seven cages numbering eight per group were used for this study. Parameters investigated in this study includes Malondialdehyde (μg/ml), glutathione (μg/ml), fasting blood sugar (mmol/l) and weight in grammes.Group1 was assign the normal control while group2 to seven serve as the test groups Findings from this study indicate a significant decrease in the final weight in groug5 (147g) and group7 (173g) that received 1500mg/kg extract of Cyperus Esculentus, 700mg/kg phoenix dactylifera fruit daily and 472mg/kg liquid cod liver oil per body weight daily. This decrease was closely followed by group2 (147g),group6 (171g) and group3 (193g) that receive 100mg/kg extracts of Cyperus Esculentus only, combination of 1600mg/kg Cyperus esculentus,800mg/kg phoenix dactylifera, 1200mg/kg soybean and 620mg/kg phoenix dactylifera only at the end of the study compared with the control. However there was an increase in group4 final weight that received 1000mg/kg soybean extract daily and the control. The level of glutathione with antioxidant properties increased in group2, 3, 7, 4, and 6 to 2.15, 2.59, 1.96, and 1.68 μmol/ml respectively compared with the control of 1.24 μg/ml. The level of Malondialdehyde were all decreased among the test groups compared with the control. The fasting blood sugar level in group7 that received the standard drug –cod liver oil increased from the initial level of 3.28mmol/l to 4.55mmol/l at the end of the study. Insight on these nut fruits and soybean in this study have shown a beneficial effect of decreasing fasting blood sugar level and increasing glutathione level with antioxidant properties needed to promote good health and longevity.